THE FORMATION OF 5‐HYDROXYTRYPTOPHOL IN BRAIN IN VITRO

Abstract

Kveder, Iskric & Keglevic (1962) described the formation of 5-hydroxytryptophol from 5-hydroxytryptamine (5HT) in vivo in rats. The alcohol was isolated as conjugates from urine, and distinguished from 1'-N-acetyl 5-hydroxytryptamine by paper chromatography. Feldstein & Wong (1965) demonstrated the enzymatic conversion of 5HT to 5-hydroxy- tryptophol in rat liver. The alcohol appears also to be a major metabolite of the amine in platelets (Bartholini, Pletscher & Bruderer, 1964).