Cephalochromin, dihydroiso-ustilaginoidin A, and iso-ustilagionoidin A from Verticillium SP. K-113.

Abstract

A species of Verticillium (strain K-113), an imperfect fungus, produced cephalochrominl> (Ia), iso-ustilaginoidin A2) (IIa), and a new antibiotic, dihydroiso-ustilaginoidin A (IIIa). The culture filtrate was adjusted to pH 3.0 with 2 N hydrochloric acid and extracted with ether. The mycelium was extracted with acetone and the acetone extract was further extracted with ether. The combined ether extracts were chromatographed on silicic acid and silica gel impregnated with 0.5 N oxalic acid to give compounds (la), (IIa), and (IIIa).