Topography and Temporal Evolution of Hypoxic Viable Tissue Identified by ¹⁸ F-Fluoromisonidazole Positron Emission Tomography in Humans After Ischemic Stroke

Abstract

These observations suggest that infarct expansion occurs at the expense of hypoxic tissue from the center to the periphery of the ischemic region in humans, similar to that seen in experimental animal models. These findings have important pathophysiological and therapeutic implications.