Targeting Vascular Endothelial Growth Factor Pathway Offers New Possibilities to Counteract Microvascular Disturbances During Ischemia/Reperfusion of the Pancreas

Abstract

VEGF plays a crucial causative role involving an increase in permeability in normal as well as in postischemic pancreatitis via tyrosinkinase receptors. VEGF seems to be partly accountable for a deterioration of FCD and an upregulation of LEI via VEGF-tyrosinekinase receptor independent mechanisms. VEGF might be a promising potential therapeutic target in order to minimize edema formation caused by I/R and pancreatitis in pancreas transplantation.