Increased expression of cardiac angiotensin II type 1 (AT) receptors decreases myocardial microvessel density after experimental myocardial infarction

Abstract

Microvessel density after MI is decreased when the AT(1) receptor is overexpressed, and this is amenable to AT(1) receptor blockade. This suggests that efficacy of AT(1) receptor blockers post-MI may not only be due to attenuation of LV remodeling, but also to a stimulatory effect on angiogenesis.