Response to Comment on "Little Evidence for Developmental Plasticity of Adult Hematopoietic Stem Cells"

Abstract

Both our study (1) and that of Krause et al. (2) clearly demonstrated that a single bone marrow (BM)–derived cell can fully reconstitute the hematopoietic compartment of lethally irradiated adult mice. However, these studies differed significantly in their assessment of the ability of the transplanted cell to additionally give rise to nonhematopoietic cell fates.