BMJ · 1996 · 34 citations · 3 references
PharmacyPharmacologyToxicologyClinical BiochemistryDiagnostic ToxicologyForensic ToxicologyCyanide ToxicologyHydroxocobalamin TherapyInterpretation Of Toxicology ResultsTuberculosis DiagnosisTuberculosis Diagnostic TestingAcute Cyanide PoisoningBlood Cyanide AnalysisCyanide Analytical ToxicologyCyanide BiomarkersCyanide MetabolismCyanide Poisoning TreatmentToxicological Analysis Of UrineUrine Biomarkers
CommentSystolic blood pressure was not indicative of blood cyanide levels and oxyhaemoglobin saturation gradient did not parallel decreases in blood cyanide concen- trations.Concentration decay curves suggest that plasma lactate concentration is closely related to blood cyanide concentration before and after hydroxoco- balamin treatment.If this is confirmed in other cases of pure cyanide intoxication serial plasma lactate concen- trations could be used as a marker of the evolution of cyanide toxicity and perhaps of the adequacy of treatment.
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