Palladium‐Catalyzed Oxidative Cyclization of Enynes with Hydrogen Peroxide as the Oxidant

Abstract

Gently does it: The Pd-catalyzed oxidative cyclization of enynes with hydrogen peroxide, a simple, inexpensive, and environmental benign oxidant, is proposed to proceed through a catalytic PdII/PdIV cycle in which the key CCl bond-forming step is the formation of a PdIV intermediate (see scheme). This is followed by a direct reductive elimination to generate CCl bonds with retention of the configuration of the C(sp3) center. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z801438_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.