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Isolation of Dehydroepiandrosterone and 17α-Hydroxy-δ<sup>5</sup>-Pregnenolone from the Polycystic Ovaries of the Stein-Leventhal Syndrome<sup>1</sup>
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1962
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InfertilityHormonal ContraceptiveHuman Pituitary FshEndocrine ResearchMedicinePhysiologyNeuroendocrinologyGynecologyPolycystic OvariesReproductive MedicineMicrochemical TechniquesEndocrinologyPharmacologyOvarian HormoneSteroid MetabolismEndocrine DiseaseReproductive Endocrinology
Dehydroepiandrosterone or δ4-androstenedione and 17α-hydroxyprogesterone have been isolated from the polycystic ovaries of the Stein-Leventhal syndrome using microchemical techniques. 17α-Hydroxy-δ5-pregnenolone was isolated from the ovaries of 2 patients with the Stein-Leventhal syndrome treated with human pituitary FSH before surgery. The significance of these findings is discussed.