The Journal of Clinical Endocrinology & Metabolism · 1962 · 87 citations · 0 references
MedicineBiochemistryEndocrinologyReproductive EndocrinologyReproductive MedicineSteroid BiochemistryGonadal HormonesGonadal Steroid HormonesGynecologic EndocrinologyOvarian DisordersPolycystic Ovary SyndromeSteroid Metabolism Disorders17 Alpha-hydroxylaseDehydroepiandrosterone SynthesisMicrochemical AnalysisPituitary PhysiologyPolycystic Ovarian MorphologySex Hormone Biosynthesis DisordersSex Hormone Synthesis DefectsSteroidogenic Enzyme Defects
Dehydroepiandrosterone or δ4-androstenedione and 17α-hydroxyprogesterone have been isolated from the polycystic ovaries of the Stein-Leventhal syndrome using microchemical techniques. 17α-Hydroxy-δ5-pregnenolone was isolated from the ovaries of 2 patients with the Stein-Leventhal syndrome treated with human pituitary FSH before surgery. The significance of these findings is discussed.