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A New Neuroprotective Compound of<i>Ligustrum japonicum</i>Leaves
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2006
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Ligustrum Japonicum LeavesMedicinal ChemistryBiochemistryBotanyNew Neuroprotective CompoundNatural SciencesMedicineGlycobiologyPhytochemistrySecondary MetabolitePlant PathologyPhytochemicalPlant ToxinPharmacologyN-buoh FractionNew Secoiridoid Glycoside
A new secoiridoid glycoside characterized as (8 Z)-nuezhenide A along with five known glycosides, (8 E)-nuezhenide, (8 Z)-nuezhenide, oleonuezhenide, osmanthuside B and osmanthuside D, were isolated from the n-BuOH fraction of Ligustrum japonicum leaves. All six compounds significantly protected human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.