Angiology · 2013 · 14 citations · 20 references
MedicineCardiologyPharmacologyCardiovascular PharmacotherapyClinical PharmacologyInterventional CardiologyAcute Coronary Syndrome InterventionCardiac BiomarkersCardiac PharmacotherapyCoronary Artery DiseaseMyocardial Infarction ComplicationsMyocardial ProtectionCardiac TroponinsControl Group DesignCreatine Kinase-mbMatched Control GroupMyocardial Injury AssessmentMyocardial Injury DetectionMyocardial Injury MarkersTroponin Elevation
OBJECTIVE: To evaluate the effect of exogenous creatine phosphate (CP) on myocardial injury after percutaneous coronary intervention (PCI). METHOD: Four hundred patients were divided to receive conventional therapy (control group) or 3-day intravenous infusion of CP after PCI (CP group). Levels of creatine kinase MB (CK-MB) and troponin I (TnI) were measured before and on postprocedural day 3. RESULTS: Postprocedural CK-MB and TnI in the CP group were significantly increased compared to the control group. In the CP group, 8.0% and 5.0% of patients had an increase in CK-MB 1 to 3 times and >3 times, respectively, which were significantly lower than that of the control group (19.0% and 9.0%, respectively); 12.0% and 10.0% of patients had an increase in TnI 1 to 3 times and >3 times, respectively, which were significantly lower than that of the control group (21.0% and 18.0%, respectively). CONCLUSION: Exogenous CP was helpful to reduce myocardial injury after PCI.
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The Creatine Kinase System in Normal and Diseased Human Myocardium
Joanne S. Ingwall, Martha F. Kramer, Michael A. Fifer et al. · New England Journal of Medicine · 1985 · 401 citations
Medicine, Biochemistry, Cardiology +16
Jean-Pierre Bertinchant, Anne Polge, Dania Mohty et al. · The Journal of Trauma: Injury, Infection, and Critical Care · 2000 · 266 citations