Evaluation of anti-snake venom activity of the aqueous root extract of <i>Securidaca longipedunculata</i> in rats

Abstract

The anti-snake venom properties of Securidaca longipedunculata Frens root extract have been evaluated in rats by monitoring the levels of the liver enzymes, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), creatinine kinase (CPK), lactate dehydrogenase (LDH), and amylase. The extract produced a significant (P < 0.05) dose-dependent alteration in the serum enzymes and urea analyzed. The alterations in these parameters may be responsible for pharmacologic activity of the plant extract. Keywords: Securidaca longipedunculata, serum enzymes, anti-snake venom activity Journal of Pharmacy & Bioresources Vol. 2(2) 2005: 80-83