Genes Chromosomes and Cancer · 2004 · 59 citations · 17 references
Life SciencesGeneticsMolecular GeneticsCancer GeneticsCytogeneticsOncogenesCancer CytogeneticsChromosomal TranslocationsGene Fusions In CancerLymphoid NeoplasmsMolecular CytogeneticsTranscription Factor OncogenesAcute Lymphoblastic Leukemia BiologyChromosome RearrangementsGenomic RearrangementsOncogene RearrangementsT-cell Acute Lymphoblastic LeukemiaTranscription Factor Fusion OncogenesTranscriptional ActivationTranslocations
Most chromosomal translocations observed in T-cell acute lymphoblastic leukemia (T-ALL) often produce transcriptional activation of transcription factor oncogenes. Ectopic expression of the TLX3 (also known as HOX11L2) gene has been shown to be associated with a cryptic t(5;14)(q35;q32) translocation specific for a subtype of T-ALL. Here we report several examples of variant and alternative translocations resulting in expression of TLX3 in T-ALL, and we describe three of these translocations in detail. In particular, the CDK6 gene was rearranged in two t(5;7)(q35;q21) translocations. In two additional instances, fusion of the BCL11B (also known as CTIP2) and RANBP17/TLX3 loci were shown to result from subtle genomic insertion/deletion within these loci. This study further underscores that TLX3 expression in T-ALL is strongly associated with the presence of genomic rearrangements.
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Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia
Adolfo A. Ferrando, Donna Neuberg, Jane Staunton et al. · Cancer Cell · 2002 · 1.1K citations · Full text
Bcl11b is required for differentiation and survival of αβ T lymphocytes
Yuichi Wakabayashi, Hisami Watanabe, Jun Inoue et al. · Nature Immunology · 2003 · 346 citations