12-O-tetradecanoylphorbol-13-acetate promotes tumors prior to initiation in two-stage promotion☆

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

Hartmut Land, Luis F. Parada, Robert A. Weinberg · Nature · 1983 · 2.9K citations

Medicine, Cell Biology, Genetics +16

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

H. Earl Ruley · Nature · 1983 · 1.3K citations

Life Sciences, Cell Biology, Molecular Biology +13

Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene

Robert F. Newbold, Robert W. Overell · Nature · 1983 · 444 citations

Medicine, Cell Biology, Genetics +14

THE INDUCTION OF ORNITHINE DECARBOXYLASE AS AN EARLY, POSSIBLY OBLIGATORY EVENT IN MOUSE SKIN CARCINOGENESIS

T. G. Brien · 1976 · 355 citations

Medicine, Dermatology, Oncology +10

Studies on the mechanism of skin tumor promotion: Evidence for several stages in promotion

Thomas J. Slaga, Susan M. Fischer, Kay Nelson et al. · Proceedings of the National Academy of Sciences · 1980 · 335 citations · Full text

Medicine, Oncology, Pharmacology +14