Short chain fatty acids stimulate epithelial mucin 2 expression through differential effects on prostaglandin E ₁ and E ₂ production by intestinal myofibroblasts

Abstract

SCFA can differentially regulate PG production, thus stimulating MUC-2 expression in intestinal epithelial cells. This mechanism involving functional interaction between myofibroblasts and epithelial cells may play an important role in the mucoprotective effect of bacterial fermentation products.