Planta Medica · 1994 · 85 citations · 0 references
Life SciencesBotanyMicrobiologyEthnobotanyMycologyNatural Product BiosynthesisAntifungal AgentsFungal BiochemistryFungal PathogenesisFungal Secondary MetabolitesMedicinal PlantsActive Compound IsolationAgar DilutionChemical Structure-activity RelationshipsFungal Bioactive CompoundsNatural Antifungal CompoundsNew Antifungal AgentsTerpenoid Glycosides
The antifungal activity of triterpenoid saponins, with hederagenin or oleanolic acid as aglycone, was investigated in vitro by the agar dilution method. Monodesmosidic hederagenin derivatives were shown to exhibit a broad spectrum of activity against yeast as well as dermatophyte species. alpha-Hederin was the most active compound, and Candida glabrata was the most susceptible strain. The structure-activity relationships are discussed.