High-Efficiency Loading and Controlled Release of Doxorubicin Hydrochloride on Graphene Oxide

Abstract

A novel graphene oxide−doxorubicin hydrochloride nanohybrid (GO−DXR) was prepared via a simple noncovalent method, and the loading and release behaviors of DXR on GO were investigated. An efficient loading of DXR on GO as high as 2.35 mg/mg was obtained at the initial DXR concentration of 0.47 mg/mL. The loading and release of DXR on GO showed strong pH dependence, which may be due to the hydrogen-bonding interaction between GO and DXR. The fluorescent spectrum and electrochemical results indicate that strong π−π stacking interaction exists between them.