Efficient Asymmetric Synthesisof Oseltamivir from <scp>d</scp>-Mannitol

Abstract

A highly practical asymmetric synthesis of oseltamivir has been accomplished in 18 steps from d-mannitol without any chromatographic purification, which features intramolecular aldol condensation of dialdehyde with a 3-pentyl ether moiety in constructing densely functionalized cyclohexene ring of oseltamivir.