A new semisynthetic macrolide antibiotic 3-O-oleandrosyl-5-O-desosaminylerythronolide a oxime.

Abstract

A new antibiotic, 3-O-oleandrosyl-5-O-desosaminylerythronolide A oxime (3) was produced from erythronolide A oxime (1) by the oleandomycin-producing culture, Streptomyces antibioticus ATCC 11891. The structure of 3 was determined by degradative studies and confirmed by X-ray analysis. Compound 3 was found to be less active, but more stable to acid, than erythromycin A oxime.