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Alkaloids of <i>Lycopodium</i><i>selago</i>. On the identity of selagine with huperzine A and the structure of a related alkaloid
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1989
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BiologyMolecular PharmacologyL. SelagoPharmaceutical ChemistryBiochemistryActive IngredientMedicineNatural SciencesSecondary MetabolitePhytopharmacologyPharmacotherapyRelated AlkaloidPhytochemistryPharmacologyLycopodium AlkaloidsHuperzine ADrug DiscoveryNatural Product Synthesis
Selagine, an alkaloid of Lycopodiumselago, is shown to be identical with huperzine A (2). A minor alkaloid, C 15 H 18 N 2 O 2 , isolated from L. selago is found to be 6β-hydroxyhuperzine A (4). Keywords: huperzine A, selagine, Lycopodium alkaloids, Alzheimer's disease, acetylcholine esterase inhibitor.