Endothelial Release of Nitric Oxide Contributes to the Vasodilator Effect of Adenosine in Humans

Abstract

Adenosine-induced vasodilation in humans is mediated, at least in part, by endothelial release of NO. The transducing mechanism of this phenomenon is not known, but it does not appear to involve the activation of either ATP-dependent or quinidine-sensitive potassium channels.