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Synthesis of carbon-14 labelled NK-1 receptor antagonists GR203040 and GR205171
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2000
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Molecular PharmacologyMedicinal ChemistryIodoaromatic SubstratesBiochemistryCarbon-14 AtomsMedicineNatural SciencesFunctional SelectivityImmunologyCarbon-14 Labelled VersionsReceptor (Biochemistry)G Protein-coupled ReceptorOrganic ChemistryPharmacologyPharmaceutical ChemistryEnantioselective SynthesisDrug Discovery
Syntheses of carbon-14 labelled versions of NK-1 receptor antagonists GR203040 and GR205171 are described. The carbon-14 atoms were introduced by palladium (0) catalysed cyanation of iodoaromatic substrates. Copyright © 2000 John Wiley & Sons, Ltd.