Phosphorus, sulfur, and silicon and the related elements · 2000 · 10 citations · 3 references
PharmacyChemistryMedicinal ChemistryDrug DiscoveryOrganic ChemistrySynthetic Medicinal ChemistryHeterocycle SynthesisOrganic SynthesisAldehydesNitrous AcidPyrazine ChemistryPyrazole ChemistryPyrazole SynthesisPyridazine ChemistryPyridine ChemistryPyridine Synthesis
Abstract 3-amino-4,5-diphenylthieno[2,3-c]pyridazine-2-arylcarboxamide 2 underwent cyclization with triethyl orthoformate and with nitrous acid to give the pyrimidothienopyridazines 3a-c, 4b respectively. 3-amino-4,5-diphenylthieno[2,3-c] pyridazine-2-carbohydrazide 6 reacted with aromatic aldehydes to give the corresponding carbohydrazones 7a-c. Compound 7 reacts with triethyl orthoformate, acetic anhydride or with CS2/pyridine to produce pyrimidothienopyridazines 8,9 and pyridazothienothiazine 11.
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Aminopyridazines as Acetylcholinesterase Inhibitors
Jean‐Marie Contreras, Yveline Rival, Saïd Chayer et al. · Journal of Medicinal Chemistry · 1999 · 163 citations · Full text
Sh. M. Radwan, Mohamed S. Abbady, Hussein El‐Kashef · Phosphorus, sulfur, and silicon and the related elements · 1994 · 13 citations