High incidence of <scp>DNA</scp> ploidy abnormalities and increased <scp>M</scp>cm2 expression may predict malignant change in oral proliferative verrucous leukoplakia

Abstract

Mcm2 expression and DNA ploidy analysis could be used to predict areas of malignant transformation. The clinicopathological findings associated with the immunohistochemical and DNA ploidy results support the distinct and aggressive profile of this entity.