Pharmacokinetics of a Guanfacine Extended‐Release Formulation in Children and Adolescents with Attention‐Deficit–Hyperactivity Disorder

Abstract

Guanfacine extended-release formulation demonstrated linear pharmacokinetics. Plasma concentrations and concentration-related pharmacokinetic parameters were higher in children than in adolescents. These differences are likely due to heavier body weights in adolescents and young male subjects. No serious adverse events were reported.