Stimulation of fatty acid biosynthesis by phosphorylated sugars.

Abstract

The synthesis of long-chain fatty acids (palmitic acid) from acetyl CoA and malonyl CoA has been shown to be catalyzed by a complex of six or more enzymes and a small molecular weight protein known as acyl carrier protein (ACP). 1, 2The enzyme-complex was isolated intact from animal tissue' and yeast4 but was readily dissociable into its various components in extracts of E. coli," 2 from which at least eight individual enzymes were isolated and characterized.The enzymes were found to be specific for acyl ACP derivatives, thus establishing a synthetic pathway for fatty acids different from the classical fl-oxidation pathway, although