Universal Gradient Substrates for “Click” Biofunctionalization

Abstract

Versatile templates for gradient immobilization of biomolecules by click chemistry are easily generated from reproducible and tunable surface energy gradients. An arginine–glycine–aspartate (RGD) peptide density gradient controls cell adhesion (see figure), and demonstrates the utility of this fabrication process for making substrates that can screen cell response to bioactive materials. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2007/c2221_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.