Insonation of Targeted Microbubbles Produces Regions of Reduced Blood Flow Within Tumor Vasculature

Abstract

High-pressure fragmentation of microbubbles bound to tumor endothelial receptors reduced blood flow within 2 syngeneic mouse tumor models for ∼30 minutes. Platelet activation, likely resulting from the injury of small numbers of endothelial cells, was the apparent mechanism for the flow reduction.