Different Pattern of Local and Systemic Release of Proinflammatory and Anti-inflammatory Mediators in Severely Injured Patients with Chest Trauma

Abstract

Highly increased concentrations of proinflammatory cytokines in BALF, but not in circulation, indicate a strong local inflammatory response early after multiple injuries combined with chest injury rather than severe systemic inflammation. In contrast, anti-inflammatory mechanisms seem to be activated locally and systemically.