A realistic large-scale model of the cerebellum granular layer predicts circuit spatio-temporal filtering properties

Abstract

in response to natural stimuli. These results have supported in turn four main functional hypotheses. (1) The granular layer response to mossy fi ber bursts should be spatially organized in a center-surround pattern, where the excitatory-inhibitory balance is dominated by excitation in the center and by inhibition in the surrounding areas. (2) The granular layer should generate a time-window effect limiting the duration and intensity of the GrC output (D'Angelo and De Zeeuw, 2009). ( Finally, (4) sparse GrC random activity should be able to sustain coherent low-frequency oscillations of granular layer activity However, whether and how these aspects integrate into a coherent functional framework has remained unclear.