The Effects of Inflammation on Glial Fibrillary Acidic Protein Expression in Satellite Cells of the Dorsal Root Ganglion

Abstract

Under physiologic conditions, the expression of GFAP by SCs is undetectable. As the inflammatory process develops, GFAP expression steadily increases with 100% of SCs being GFAP immunoreactive 7 days after chromic gut application. These data suggest that SCs are the primary source of GFAP in the DRG. We hypothesize that SC play an important role in the response to early inflammatory injury.