Glucocorticoid receptor expression in inflammatory bowel disease: evidence for a mucosal down‐regulation in steroid‐unresponsive ulcerative colitis

Abstract

In inflammatory bowel disease systemic and mucosal GR mRNA expression is not altered. However, in ulcerative colitis patients, low mucosal GR expression may predict the outcome of GC therapy. The low expression of GRbeta challenges its role in steroid refractoriness in inflammatory bowel disease.