BMJ · 1992 · 29 citations · 0 references
Veterinary MedicineInfectious DiseasesMicrobiologyAntimicrobial PharmacologyAntimicrobial PharmacotherapyMedical MicrobiologyAntibacterial TherapyAntimicrobial TherapyBactericidal AgentsMinocycline TherapyRifampicin Therapy
Unfortunately, because the safety ofprolonged courses of fluoroquinolones has not been established they cannot be recommended for treating leprosy.Minocycline, however, has been used for over two decades, primarily for other bacterial diseases and acne; because of its safety record in long term use our findings strongly support its application to the treat- ment of leprosy.Minocycine may also be a second bactericidal agent to combine with rifampicin treatment and thereby shorten the duration of treatment required to treat leprosy effectively.