GROWTH-PROMOTING AND LUTEOTROPHIC ACTIVITIES OF HUMAN GROWTH HORMONE

Abstract

SUMMARY Human growth hormone prepared by Raben's (1959) method was chromatographed on various ion exchangers and the resulting fractions were assayed for growth-promoting, luteotrophic and immunological activity. A critical quantitative study of the biological activities of the fractions showed that there were significant differences between their ratios of growth-promoting to luteotrophic potency. The luteotrophic activity of some of the preparations was slightly higher than that of the 2nd International Ovine Prolactin Standard.