Participation of Brown Fat in Pathogenesis of Experimental Poliomyelitis of Monkeys.

Abstract

SummaryFollowing peripheral inoculation, poliomyelitis virus (Type I) proliferates in the brown fat of cortisone-treated monkeys during the preparalytic and paralytic stages of the disease. On subsequent peripheral passage of infected brown fat, the virus can be detected in the brown fat in the absence of cortisone treatment. Characteristic brown fat lesions are incidental to viral proliferation.