British Journal of Clinical Pharmacology · 1982 · 54 citations · 2 references
PharmacyPharmacokineticsPharmacologyBioavailabilityClinical PharmacologyGeriatric PharmacokineticsAge-related Pharmacokinetic DifferencesAge-related PharmacokineticsBioavailability AnalysisDrug Distribution In Older AdultsAge-dependent PharmacokineticsAge-related Bioavailability VariabilityAntihypertensive Drug TherapyFirst-pass Metabolism EffectsHypertension In Older AdultsPharmacokinetics In AgingPharmacokinetics In Elderly PatientsVariable Bioavailability
The antihypertensive drug labetalol was administered orally and intravenously to ten hypertensive patients aged between 28 and 75 years. There was a significant increase with age in both bioavailability and half-life of labetalol. Clearance tended to be lower in the elderly subjects. First pass metabolism results in variable oral bioavailability of labetalol which is greater in the elderly and this should be borne in mind when using the drug in this age group.
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