The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis

The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate

Craig McCormick, Gillian Duncan, K. Tina Goutsos et al. · Proceedings of the National Academy of Sciences · 2000 · 440 citations

Life Sciences, Genetics, Molecular Biology +15

Cloning of the putative tumour suppressor gene for hereditary multiple exostoses (EXT1)

Jung Ahn, Hermann‐Josef Lüdecke, Steffi Lindow et al. · Nature Genetics · 1995 · 430 citations

Life Sciences, Genetics, Molecular Genetics +8

The Putative Tumor Suppressors EXT1 and EXT2 Are Glycosyltransferases Required for the Biosynthesis of Heparan Sulfate

Thomas Lind, Frank Tufaro, Craig McCormick et al. · Journal of Biological Chemistry · 1998 · 425 citations · Full text

Life Sciences, Biochemistry, Genetics +15

The putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfate

Craig McCormick, Yves Leduc, Diane Martindale et al. · Nature Genetics · 1998 · 384 citations

Medicine, Cell Biology, Molecular Biology +14

Hedgehog Movement Is Regulated through tout velu–Dependent Synthesis of a Heparan Sulfate Proteoglycan

Inge The, Yohanns Bellaı̈che, Norbert Perrimon · Molecular Cell · 1999 · 370 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13