Adenosine 3′,5′-Monophosphate in Pancreatic Islets: Glucose-Induced Insulin Release

Abstract

Glucose-induced release of insulin from perifused rat islets is associated with elevated islet adenosine 3′,5′-monophosphate. If values for adenosine 3′,5′-monophosphate are compared to insulin release during theophylline or glucose stimulation and theophylline plus glucose stimulation, it suggests a minor role for adenosine 3′,5′-monophosphate in directly stimulating insulin release but a prominent role in modulating glucose-induced release of insulin.