Apoptosis is induced in leishmanial cells by a novel protein kinase inhibitor withaferin A and is facilitated by apoptotic topoisomerase I–DNA complex

The mechanism of topoisomerase I poisoning by a camptothecin analog

Bart L. Staker, Kathryn A. Hjerrild, M.D. Feese et al. · Proceedings of the National Academy of Sciences · 2002 · 802 citations · Full text

Medicine, Oncology, Pharmacology +14

Induction of a Common Pathway of Apoptosis by Staurosporine

Richard Bertrand, Éric Solary, Patrick M. O’Connor et al. · Experimental Cell Research · 1994 · 508 citations

Life Sciences, Cell Biology, Molecular Biology +12

Camptothecin induced mitochondrial dysfunction leading to programmed cell death in unicellular hemoflagellate Leishmania donovani

Nilkantha Sen, Benu Brata Das, Anirban Ganguly et al. · Cell Death and Differentiation · 2004 · 233 citations · Full text

Life Sciences, Cell Biology, Pharmacology +16

Selected Novel Flavones Inhibit the DNA Binding or the DNA Religation Step of Eukaryotic Topoisomerase I

Fritz Boege, Tobias Straub, Albrecht Kehr et al. · Journal of Biological Chemistry · 1996 · 225 citations · Full text

Medicine, Oncology, Pharmacology +13

Ionizing radiation stimulates unidentified tyrosine-specific protein kinases in human B-lymphocyte precursors, triggering apoptosis and clonogenic cell death.

Fatih M. Uckun, L Tuel-Ahlgren, C. W. Song et al. · Proceedings of the National Academy of Sciences · 1992 · 194 citations · Full text

Medicine, Immunology, Apoptosis +16