Quinidine-Induced Lupus Nephritis

Abstract

MANY DRUGS can precipitate a syndrome resembling systemic lupus erythematosus (SLE). The most common are hydralazine hydrochloride, procainamide hydrochloride, and various anticonvulsants. To our knowledge, only two previous cases of quinidine-related lupus have been recorded.^1,2Our case involved the musculoskeletal system and the kidneys. <h3>Case Report</h3> A 49-year-old woman was first admitted to Holy Redeemer Hospital in August 1970 with a diagnosis of rheumatic mitral stenosis with atrial fibrillation. At that time, the antistreptolysin O titer, hemoglobin value, blood cell count, and urinalysis results were normal. Digoxin therapy was started with a dosage of 0.25 mg daily. The patient was also receiving warfarin sodium (Coumadin), 7.5 mg daily, and meprobamate, 200 mg four times a day. Her rhythm reverted to normal with digoxin therapy. The patient remained well until July 1973, when she was readmitted because of recurrence of atrial fibrillation with an uncontrolled ventricular response. Her treatment consisted