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97Ru-DMSA for delayed renal imaging.
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1981
Year
Renal FunctionTin-free PreparationClinical ChemistryChronic Kidney DiseaseRenal PharmacologyNuclear MedicineRadiologyHealth SciencesDelayed Renal ImagingMedical ImagingSodium HomeostasisRenal PathophysiologyRadiologic ImagingRenal CortexUrologyDimercaptosuccinic AcidBiomedical ImagingMedicineNephrologyKidney ResearchDrug Discovery
Dimercaptosuccinic acid (DMSA) was labeled with 97Ru both with and without the addition of SnCl.2H2O. The tin-containing preparation was found to induce higher cortical deposition of 97Ru-DMSA than the tin-free preparation. Visualization of the renal cortex was excellent 4 to 48 hours after injection in normal dogs with renal insufficiency. It is concluded that 97Ru-(Sn+2)-DMSA is a potentially useful renal imaging agent when delayed scintigraphy is necessary because of decompensaton of the kidneys.