In Vivo Genome-Wide Expression Study on Human Circulating B Cells Suggests a Novel<i>ESR1</i>and<i>MAPK3</i>Network for Postmenopausal Osteoporosis

Abstract

This is the first in vivo genome-wide expression study on human B cells in relation to osteoporosis. Our results highlight the significance of B cells in the etiology of osteoporosis and suggest a novel mechanism for postmenopausal osteoporosis (i.e., that downregulation of ESR1 and MAPK3 in B cells regulates secretion of factors, leading to increased osteoclastogenesis or decreased osteoblastogenesis).