Interval Mapping in the Analysis of Nonadditive Quantitative Trait Loci

Abstract

A method for detecting the linkage between an interval defined by a pair of markers and a nonadditive quantitative trait locus for F2 populations is presented. The method uses the EM algorithm to estimate the biometrical parameters and the locations of the quantitative trait loci. A computationally efficient approach suitable for implementation on a personal computer (PC) has been developed. The method has been applied to 100 replicated sets of 250 simulated individuals. Two criteria, the LOD score and the Fisher-Snedecor F, are compared in terms of their power and Type I error.