Environmental and Molecular Mutagenesis · 1990 · 102 citations · 10 references
PharmacyOncologyToxicologyCarcinogenesisMechanisms Of ToxicityMolecular ToxicologyCarcinogenic MechanismsCarcinogenicity AssessmentMutagenicity AssessmentRodent ToxicologyCancer Risk AssessmentCarcinogenicity Risk AssessmentIn Vitro Resistance AssaysLymphoma ResistanceMammalian Cell Mutagenicity AssaysMouse Lymphoma AssayShort-term Toxicity Assessment
Forty-one chemicals were tested for their abilities to induce trifluorothymidine resistance in L5178Y mouse lymphoma (MOLY) cells. These chemicals were included in the National Toxicology Program's evaluation of four in vitro short-term toxicity assays for predicting carcinogenicity in the rodent bioassay. Of the 41 chemicals examined for this report, 8 were equivocal in the rodent bioassay, and 7 were questionable in- the MOLY assay. If these chemicals are eliminated from an analysis of concordance, the remaining 26 chemicals lead to a concordance of 69% with a sensitivity of 71%. The specificity could not be determined because only two non-carcinogens were detected.
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Prediction of Chemical Carcinogenicity in Rodents from in Vitro Genetic Toxicity Assays
Raymond W. Tennant, Barry H. Margolin, Michael D. Shelby et al. · Science · 1987 · 817 citations
Pharmacy, Genetics, Toxicology +17
Errol Zeiger, Joseph K. Haseman, Michael D. Shelby et al. · Environmental and Molecular Mutagenesis · 1990 · 232 citations
Pharmacy, Genetics, Toxicology +17