ISOLATION AND STRUCTURE OF RIFAMYCIN L AND ITS BIOGENETIC RELATIONSHIP WITH OTHER RIFAMYCINS

Abstract

Incubation of rifamycin S with washed mycelium of Streptomyces mediterranei gives rifamycin B, rifamycin Y and a new substance named rifamycin L. The structure of the latter has been established as the 4-glycolyl ester of rifamycin SV. The glycolic moieties of rifamycin B and L appear to have the same origin. The biogenetic relationships of these rifamycins are discussed.