Recovery of Endothelial Function in Severe Falciparum Malaria: Relationship with Improvement in Plasma<scp>l</scp>‐Arginine and Blood Lactate Concentrations

Abstract

Recovery of endothelial function in severe malaria is associated with recovery from hypoargininemia and lactic acidosis. Agents that can improve endothelial NO production and endothelial function, such as L-arginine, may have potential as adjunctive therapy early during the course of severe malaria.