Kinetic studies of normal and variant hypoxanthine phosphoribosyltransferases in intact fibroblasts

Statistical estimations in enzyme kinetics

GN WILKINSON · Biochemical Journal · 1961 · 3.6K citations · Full text

Life Sciences, Biochemistry, Chemical Kinetics +15

A familial disorder of uric acid metabolism and central nervous system function

Michael Lesch, William L. Nyhan · The American Journal of Medicine · 1964 · 1.5K citations

Life Sciences, Neurology, Neuroscience +9

Enzyme Defect Associated with a Sex-Linked Human Neurological Disorder and Excessive Purine Synthesis

J. Edwin Seegmiller, Frederick M. Rosenbloom, William N. Kelley · Science · 1967 · 1.2K citations

Life Sciences, Biochemistry, Neurology +14

Kinetic Studies of Hypoxanthine-Guanine Phosphoribosyltransferase

Jane Henderson, Larry W. Brox, W. N. Kelley et al. · Journal of Biological Chemistry · 1968 · 151 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Hypoxanthine‐guanine phosphoribosyltransferase variants: Correlation of clinical phenotype with enzyme activity

T Page, Bohdan Bakay, Erkki Nissinen et al. · Journal of Inherited Metabolic Disease · 1981 · 150 citations

Life Sciences, Genetics, Molecular Genetics +13