ED50and ED95of Intrathecal Hyperbaric Bupivacaine Coadministered with Opioids for Cesarean Delivery

Abstract

The ED95 of intrathecal bupivacaine under the conditions of this study is considerably in excess of the low doses proposed for cesarean delivery in some recent publications. When doses of intrathecal bupivacaine less than the ED95, particularly near the ED50, are used, the doses should be administered as part of a catheter-based technique.