Circulation · 1952 · 29 citations · 4 references
PharmacyPharmacologyPharmacotherapyBioavailabilityBiopharmaceuticsDrug DeliveryDigital TherapeuticsIncretin-based TherapiesIndividual Therapeutic RangePrescription Digital TherapeuticsTherapeutic Dose Range
The therapeutic ranges of amorphous gitalin, digitalis leaf, digitoxin and Digoxin were compared in terms of rapid and slow methods for initial digitalization and maintenance of the digitalized patient. Gitalin (amorphous) possesses a therapeutic range greater than any available digitalis preparation or glycoside. In a group of 18 ambulatory patients, gitalin (amorphous) was found to possess an average of 41 per cent increase in therapeutic range when compared with digitalis leaf. Advantages of the use of gitalin (amorphous) as compared with other digitalis preparations are discussed.
4
Robert C. Batterman, Arthur C. DeGraff · American Heart Journal · 1947 · 46 citations
Arthur C. DeGraff · Journal of the American Medical Association · 1948 · 25 citations
Medicine, Cardiology, Pharmacology +10