Iatrogenic Asthma Associated with Adrenergic Aerosols

Abstract

Article1 November 1966Iatrogenic Asthma Associated with Adrenergic AerosolsJOHN F. KEIGHLEY, M.B.JOHN F. KEIGHLEY, M.B.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-5-985 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBecause of their speed and effectiveness sympathomimetic aerosols have become established as one of the mainstays in the management of the reversible component of diffuse airway obstruction. Although the early clinical application of these aerosols is almost entirely based on short-term challenge experiments often conducted in normal subjects, there is now a tendency to study the response of asthmatic patients over more prolonged periods of time (1-4). The recognized side effects of sympathomimetic aerosols (5) are generally attributable to excessive systemic absorption, and sudden death may occur in the asthmatic when adrenergic drugs are used to excess (6-8). In addition,...References1. KENNEDYTHURSBY-PELHAM MCDC: Some adrenergic drugs and atropine methonitrate given by inhalation for asthma: a comparative study. Brit. Med. J. 1: 1018, 1964. CrossrefMedlineGoogle Scholar2. ALTOUNYAN RE: Variation of drug action on airway obstruction in man. Thorax 19: 406, 1964. CrossrefMedlineGoogle Scholar3. COHENHALE AAFC: Comparative effects of isoproterenol aerosols on airway resistance in obstructive pulmonary diseases. Amer. J. Med. Sci. 249: 309, 1965. CrossrefMedlineGoogle Scholar4. SCHERREAEPLI MR: Lung function and bronchodilating drugs, in Bronchitis, edited by ORIE, N. G. M., SLUITER, H. J. Royal Vangorcum, Assen, The Netherlands, 1964, pp. 273-281. Google Scholar5. 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Author, Article, and Disclosure InformationAffiliations: Syracuse, New YorkFrom the Medical Service, Veterans Administration Hospital, and the Department of Medicine, State University of New York, Upstate Medical Center, Syracuse, N. Y.Portions of this study were presented before the 25th Research Conference in Pulmonary Diseases of the VA-Armed Forces, January 23 through 27, 1966, Cincinnati, Ohio.Requests for reprints should be addressed to John F. Keighley, M.B., Veterans Administration Hospital, Irving Ave., Syracuse, N. Y. 13210. 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MORTALITY AND MODERN THERAPYSevere status asthmaticus: Prolonged treatment with assisted ventilation 1 November 1966Volume 65, Issue 5Page: 985-995KeywordsAdverse reactionsAsthmaCorticosteroid therapyDrug absorptionEosinophiliaHospital medicineInhalationIsoproterenolMedical servicesPulmonary diseases Issue Published: 1 November 1966 PDF DownloadLoading ...